Key features of the MET system
MET nanoparticles protect encapsulated drugs and peptides from degradation in biological fluids i.e. in the blood, stomach or intestine (top left). Polymeric micelles are very stable. This means MET is safer than some current excipients such as Tween 80 (e.g. they do not destroy erythrocytes, top middle). The MET nanoparticles enhance transport by increasing dissolution and enhancing transcellular transport (e.g., top right). Their bioadhesive properties allow them to adhere to barriers [e.g. brain capillaries showing MET nanoparticles one hour after intravenous injection (bottom right)]. In the gut the MET particles penetrate the mucus layer (bottom middle) and adhere to the intestinal villi for prolonged periods of time (bottom right).