MET Applications

MET nanomaterials have the ability to increase bioavailability of hydrophobic drugs and peptides across biological barriers such as the Cornea, the Gut, or the blood-brain-barrier (BBB). Topical application of MET predinisolone formulations achieve comparable concentrations in the eye using only 1/10th of the dose (top left). Oral bioavailability of griesofulvin (top middle) and cyclosporine (top right) is increased around six-fold. Delivery of propofol across the BBB induces anaesthesia; the duration achieved with MET carriers is 10-fold higher than that achieved with Diprivan(R) at the same dose and concentration. A more concentrated formulation leads to a further dramatic increase in duration (bottom right). MET carriers are also efficient at carrying peptides derivatives e.g. of enkephalin, a small endogenous peptide analgesic, across the BBB (middle) and can actually be used to create ‘peptide pills’ in which such peptides have oral bioavailability (bottom right).