<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Uchegbu, I. F.</style></author><author><style face="normal" font="default" size="100%">Sadiq, L.</style></author><author><style face="normal" font="default" size="100%">Arastoo, M.</style></author><author><style face="normal" font="default" size="100%">Gray, A. I.</style></author><author><style face="normal" font="default" size="100%">Wang, W.</style></author><author><style face="normal" font="default" size="100%">Waigh, R. D.</style></author><author><style face="normal" font="default" size="100%">Schätzlein, A.G.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Quarternary ammonium palmitoyl glycol chitosan- a new polysoap for drug delivery</style></title><secondary-title><style face="normal" font="default" size="100%">International Journal of Pharmaceutics</style></secondary-title><short-title><style face="normal" font="default" size="100%">Int. J. Pharm.</style></short-title></titles><dates><year><style  face="normal" font="default" size="100%">2001</style></year></dates><volume><style face="normal" font="default" size="100%">224</style></volume><pages><style face="normal" font="default" size="100%">185-199</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">A new polysoap, quaternary ammonium palmitoyl glycol chitosan (GCPQ, Mw=178,000 g mole-1) with drug solubilising potential has been synthesised and characterised. In solution hydrophobic domains of GCPQ polymeric micelles were identified by the hypsochromic shift in the l max of methyl orange and by the increase in the ratio of the fluorescence emission intensity of the third and first pyrene vibronic peaks (I3/I1). At high aqueous concentrations (&gt;10 mg ml-1) GCPQ presents as a gel which solubilises pyrene (2.5 mM, normal solubility in water ~ 2 mM) on probe sonication. Dilution of the gel to a liquid solution of polymeric micelles (=&lt;3.75 mg ml-1 of GCPQ), results in the observation of fluorescent pyrene excimers (excited dimers) and a high excimer to monomer fluorescence ratio (IE/IM). However, attempts to solubilise pyrene at a concentration of 2.5 mM in a liquid solution of GCPQ (3.75 mg ml-1) results in a reduced IE/IM value and pyrene precipitation. Viscometry measurements show a more compact conformation for the polymer solubilising pyrene than the polymer alone. The polymer is non-haemolytic when present as the liquid solution and relatively non cytotoxic. In conclusion, a new biocompatible polysoap (potential drug solubiliser) is described which forms hydrophobic domains in solution and shows hysteresis in its solubilisation of pyrene.;</style></abstract><notes><style face="normal" font="default" size="100%">IntJPharm 1.495</style></notes><label><style face="normal" font="default" size="100%">ASPAPER</style></label></record></records></xml>